MAGNESIUM & NIACIN + MANUKA HONEY. Supports Tiredness & Fatigue* Contains authentic New Zealand Manuka honey powder MGO 300 With Magnesium & Niacin to help ease tiredness & fatigue* Magnesium, Niacin & Biotin contribute to normal functioning of the nervous system & normal psychological function* Added Rhodiola, Bee pollen & 5HTP Suitable for vegetarians Contains: 30 Capsules Description A dietary supplement to help ease tiredness and fatigue and help contribute to the maintenance of a normal functioning nervous system and psychological function. Each capsule contains Niacin (Vitamin B3), Magnesium & Biotin plus 5-HTP, Bee Pollen, Freeze Dried Manuka Honey & Rhodiola Extract. The Mānuka honey is sourced from our very own Manuka Doctor hives nestled in the luscious green mountains of New Zealand. The honey is freeze dried into powder form and added to our formula which is lovingly made in the UK to the very highest standard. The MGO (methylglyoxal) level in Mānuka Honey is derived from DHA (dihydroxyacetone) which is naturally present in the nectar of the Mānuka Bush. Relax* is a combination supplement packed with nutrients and ingredients that may help reduce tension and strain, while relieving low energy and fatigue. Read on to find out more: Manuka honey (MGO 300) This high-strength honey, made by bees collecting nectar from New Zealand Manuka bushes, contains the active ingredient methylglyoxal (MGO), which has an antimicrobial [1] and also anti-bacterial effect on the body, according to a 2018 study by Ulster University. [2] Our Manuka honey is harvested from Manuka Doctor hives high in the New Zealand mountains, and then freeze-dried into powder. Bee pollen Collected by bees to turn into ‘bee bread’ for food, this ingredient may ease symptoms of stress and fatigue: a 2015 study by the Medical University of Silesia, Poland found that bee pollen can improve the blood supply to the body’s nervous system, helping to reduce stress and also physical and mental tiredness. [3] Magnesium According to the European Commission, magnesium, a key player in hundreds of enzyme reactions in the body, including energy production, can help reduce feelings of tiredness and fatigue. It’s also needed to help your nervous system function normally and for optimum psychological health. [4] An important US 2016 study reported that the body needs magnesium to create and send messages between neurons. [5] Magnesium is found in green leafy vegetables, nuts, pulses and wholegrains. [6] Vitamin B3, or niacin This B-vit, needed for multiple enzyme reactions in the body, can help reduce feelings of tiredness and fatigue, and is needed for normal nervous system function and for psychological health, according to the European Commission. [7] A 2019 study by the Tor Vergata University of Rome found niacin is needed for the development and survival of neurons. [8] Niacin is found in poultry, beef, fish, nuts, grains and pulses. [9] Biotin Another B-vitamin, biotin, is needed to help your nervous system function normally and for optimum psychological health, says the European Commission. [10] Found in beef liver, eggs and salmon, [11] biotin is involved in the delivery of glucose to the brain. [12] Rhodiola rosea For centuries, the herb rhodiola rosea was used as a traditional remedy for anxiety, depression and tiredness in Russia and Scandinavia. Today, rhodiola roots are considered adaptogens – the name given to a type of plant that may curb the effects of stress on the body. Rhodiola can slow the release of stress hormones while giving energy levels a boost, according to a 2018 study in International Journal of Psychiatry in Clinical Practice. [13] 5-HTP This is a compound our bodies create from the amino acid tryptophan, and we need it to make serotonin – an important neurotransmitter that helps to balance and regulate your mood. [14] Some researchers think that taking 5-HTP in supplement form is useful, and may help soothe panic, for example. [15] *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent disease. Sources 1. Alvarez-Suarez JM, et al. The Composition and Biological Activity of Honey: A Focus on Manuka Honey. Foods. 2014 Sep;3(3):420-432. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302252/ 2. Johnston M, et al. Antibacterial activity of Manuka honey and its components: An overview. AIMS Microbiology. 2018. 4(4):665-664. https://www.aimspress.com/fileOther/PDF/microbiology/microbiol-04-04-655.pdf 3. Komonsinska-Vassev K, et al. Bee Pollen: Chemical Composition and Therapeutic Application. Evid Based Complement Alternat Med. 2015;2015:297425. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377380/ 4. European Commission. EU Register of nutrition and health claims made on foods. http://ec.europa.eu/food/safety/labelling_nutrition/claims/register/public/?event=register.home 5. Greenblatt J. Magnesium: the missing link in mental health. IMMH. 2016. http://www.immh.org/article-source/2016/11/17/magnesium-the-missing-link-in-mental-health 6. National Institutes of Health. Magnesium: Fact Sheet for Health Professionals. https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/ 7. As Source 4 8. Gasperi V, et al. Niacin in the Central Nervous System: An Update of Biological Aspects and Clinical Applications. Int J Mol Sci. 2019 Feb; 20(4): 974. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412771/ 9. National Institutes of Health. Niacin: Fact Sheet for Health Professionals. https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional/ 10. As Source 4 11. National Institutes of Health. Biotin: Fact Sheet for Health Professionals. https://ods.od.nih.gov/factsheets/Biotin-HealthProfessional/ 12. Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy – A Review. Nutrients. 2016 Feb; 8(2):68. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772032/ 13. Anghelescu IG, et al. Stress management and the role of Rhodiola rosea: a review. Int J Psychiatry Clin Pract. 2018 Jan 11:1-11. https://www.ncbi.nlm.nih.gov/pubmed/29325481 14. Medical News Today. What are the health benefits of 5-HTP? https://www.medicalnewstoday.com/articles/324025.php 15. Schruers K, et al. Acute L-5 hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients. Psychiatry Research. Vol 113, Issue 3, 30 Dec 2002, 237-243. https://www.sciencedirect.com/science/article/abs/pii/S0165178102002627 Supplement Facts Directions & Warnings DIRECTIONS: Take one capsule per day with a meal and do not exceed this recommended daily dose. This product should not be used as a substitute for a varied, balanced diet and healthy lifestyle. Please keep out of reach from children. WARNINGS: Discontinue use and consult a doctor if adverse reactions occur. Avoid this product if you have allergies to pollen, bees or bee products. Do not use this product without first consulting with your doctor if you are under medical supervision, on prescribed medication, pregnant, breastfeeding, have asthma or related allergies. Do not use if sufferingfrom liver or kidney disease. Suitable for vegetarians.